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Tristains

S10161

Quercetin dihydrate

$36.52 – $45.52

CAS No
6151-25-3
Synonym(s)
2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one dihydrate,  3,3′,4′,5,7-Pentahydroxyflavone dihydrate
Molecular Formula:
C17H19ClN2O
Molecular Weight:
338.27
EC Number:
–
Colour Index Number:
–
PubChem CID:
5284452
MDL number:
–
Specification SDS

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Description

Buy High Quality Quercetin dihydrate (6151-25-3) MF: C15H10O7•2H2O | MW: 338.27. from Tristains.

Quercetin dihydrate is a naturally occurring flavonoid compound that is derived from various plant sources. It is commonly found in fruits, vegetables, and grains, and it is known for its antioxidant and anti-inflammatory properties.

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Applications: Antioxidant Activity: Quercetin dihydrate is a potent antioxidant, meaning it can help neutralize harmful free radicals in the body. Free radicals are unstable molecules that can cause oxidative stress, leading to cellular damage. By scavenging free radicals, quercetin dihydrate may help protect cells from oxidative damage and contribute to overall health.Anti-Inflammatory Effects: Quercetin dihydrate has been found to possess anti-inflammatory properties. It may help reduce inflammation by inhibiting the production and release of pro-inflammatory substances in the body. This makes it potentially useful in managing inflammatory conditions and supporting overall immune health.Cardiovascular Health: Some research suggests that quercetin dihydrate may have positive effects on cardiovascular health. It may help improve endothelial function, reduce blood pressure, and support healthy cholesterol levels. These effects contribute to the potential cardiovascular benefits of quercetin dihydrate.Allergy Relief: Quercetin dihydrate has been investigated for its potential anti-allergic properties. It may help inhibit the release of histamine and other allergic mediators, which can help alleviate symptoms of allergic conditions such as hay fever and allergic asthma. However, more research is needed to establish its efficacy in this regard.Potential Anti-Cancer Effects: Quercetin dihydrate has been studied for its potential anti-cancer properties. It may exert anti-cancer effects by inhibiting the growth and proliferation of cancer cells, inducing cell death, and inhibiting tumor angiogenesis. However, further research is necessary to understand its exact mechanisms and potential applications in cancer treatment.

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TECHNICAL INFORMATION
Alternate Names 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one dihydrate,  3,3,4,5,7-Pentahydroxyflavone dihydrate
Application Quercetin Dihydrate is a natural flavonoid antiproliferative kinase inhibitor
CAS Number 6151-25-3
Molecular Weight 338.27
Molecular Formula C15H10O7•2H2O
Supplemental Information This is classified as a Dangerous Good for transport and may be subject to additional shipping charges

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Quercetin Dihydrate is the dihydrate preparation of Quercetin, a ubiquitous natural flavonoid with antiproliferative properties. Quercetin is described to inhibit PLA2 and PI 3-kinase (IC50 = 3.8 microM), blocking the ATP binding site of this kinase and interrupting the role of this enzyme in propagating cellular responses to growth factors. Quercetin is further described to inhibit nucleotide-dependent kinase enzymes through competition with ATP and GTP, demonstrating inhibition of pp60src phosphotransferase, tyrosine protein kinase, calcium- and phospholipid-dependent protein kinase, and cyclic GMP phosphodiesterases. Inhibition of PI 4-kinase (1-phosphatidylinositol 4-kinase) and PI-4-phosphate 5-kinase (1-phosphatidylinositol 4-phosphate 5-kinase) by Quercetin blocks the participation of these enzymes in signal transduction pathways and reduces cellular levels of the second messenger IP3 (inositol 1,4,5-trisphosphate), decreasing the release of intracellular Ca2+ stores. The antiproliferative and cytotoxic effects of Quercetin on cultured breast cancer cells are attributed to inhibition of PI 4-kinase and PI-4-phosphate 5-kinase, reduction of IP3 levels, and blockade of oncogenic growth signaling. Quercetin was shown to induce apoptosis in tumor cell lines at the G1 and S phases. Potential fatty acid synthase, PKC, and ATP5 (mitochondrial ATPase) inhibitor as well as an SIRT1 activator. SIRT1 deacetylates histones. Quercetin Dihydrate is an inhibitor of Pim-1 and an activator of GPR30.

TECHNICAL INFORMATION

Physical State Solid
Solubility Soluble in DMSO (68 mg/ml at 25° C), Acetic Acid (1 mg/ml), Aqueous Alkali (1 mg/ml), water (<1 at 25° C), and ethanol (21 mg/ml at 25° C).
Storage Store at room temperature
Melting Point 310-315° C
Refractive Index n20D 1.82 (Predicted)
IC50 Monoamine oxidase A: IC50 = 10 nM (bovine); CYP19: IC50 = 12 nM (human); Aldose Reductase: IC50 = 14.8 nM (human); Pim-1: IC50 = 43 nM (human); CYP1B1: IC50 = 77 nM (human)
Ki Data D4DR: Ki= 7.8 nM (human); Enoyl-acyl-carrier protein reductase: Ki= 22 nM (plasmodium falciparum); CYP1B1: Ki= 23 nM (human); 5′-nucleotidase: Ki= 45.3 nM (rat); CYP1A1: Ki= 660 nM (human)

SAFETY INFORMATION

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany 3
RTECS LK8950000
PubChem CID 5284452
Merck Index 14: 8034
MDL Number MFCD00149487
EC Number 204-187-1
Beilstein Registry 317313
SMILES C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O.O.O

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