Buy High Quality Sirius Red (2610-10-8) MF: C45H26N10Na6O21S6 | MW: 1373.07. from Tristains.
Sirius Red is a histological stain used to visualize collagen fibers in various tissues. It is a mixture of dyes, primarily Sirius Red F3B and Sirius Red 4B.
“TriStains”, Histological Stains/Biological Stains that offer range of stains used in Histology, Cytology, Microbiology and Hematology laboratories.
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Applications: Collagen Visualization: Sirius Red is commonly used to stain collagen fibers in tissue sections. It selectively binds to collagen, resulting in a red or orange color under microscopy. It allows researchers to examine and quantify collagen content, distribution, and organization in different tissues, including skin, liver, heart, kidney, and lung.Fibrosis Assessment: Sirius Red staining is widely employed in the assessment of fibrosis, a pathological condition characterized by excessive collagen deposition in tissues. By staining collagen fibers, Sirius Red enables the evaluation of fibrotic changes and the extent of fibrosis in affected tissues. This staining technique is valuable in studying diseases such as liver fibrosis, pulmonary fibrosis, and cardiac fibrosis.Tissue Engineering and Regenerative Medicine: Sirius Red staining is also utilized in tissue engineering and regenerative medicine. It allows researchers to assess the deposition and remodeling of collagen fibers in engineered tissues and scaffold materials. This information helps evaluate the structural integrity and functional properties of engineered tissues.Research in Cancer and Tumor Microenvironment: The tumor microenvironment often exhibits alterations in collagen architecture and deposition. Sirius Red staining can be employed to investigate changes in collagen organization and density within tumor tissues. It provides insights into the tumor-stroma interaction and its impact on tumor progression and metastasis.Quantitative Analysis: Sirius Red staining can be combined with image analysis techniques to quantify collagen content and assess various parameters related to collagen structure, such as fiber thickness, density, and orientation. This quantitative analysis enables researchers to obtain objective measurements and compare collagen-related parameters between different samples or experimental conditions.
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