Curcumin, C.I. 75300

Description

Curcumin, C.I. 75300 CAS: 458-37-7 | MF: C21H20O6 | MW: 368.38, Buy now Histological Stains & Dyes for Histology, Cytology, Microbiology, Hematology & Biology Lab from TriStains. All Tristains products are exclusively distributed by Dawn Scientific Inc.

Curcumin (CI 75300) is a natural dye derived from the turmeric plant (Curcuma longa). Curcumin is a bright yellow-orange pigment that is soluble in ethanol and dimethyl sulfoxide (DMSO) but has limited solubility in water. The chemical formula of Curcumin is C21H20O6. It is also known as (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane, Diferulylmethane, Natural Yellow 3. curcumin (CI 75300) stain offers a range of benefits in biological staining and analytical chemistry, making it a valuable tool in scientific research and industry.

TriStains provides a marketplace for histology and biological stains, which is comprehensive enough to encompass the peculiar requirements of laboratories specializing in Histology, Cytology, Microbiology, and Hematology. With a reputation for exceeding quality expectations, TriStains performance is outstanding which allows for resolution of cell and tissue components fundamental to life sciences to be clearly visualized. Each product under TriStains series is validated for accuracy, reliability and consistency. TriStains, which manufactures and markets stains and indicators in various packing, offers laboratories turn key solutions for all their staining and indicator needs, improving accuracy in every experiment.

Application :

Curcumin is commonly used in biological staining techniques, particularly in histology and cytology.
Curcumin is used as a complexometric indicator for boron. It reacts with boric acid to form a red-colored compound, rosocyanine.

Benefits :

Gives reliable and accurate results
As an anti-inflammatory agent
Cost-effective and easy to use

Additional information

Brand	Tristains
Size	25g, 5g

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TECHNICAL INFORMATION

Application	Curcumin is a yellow-orange dye, NOS2 regulator, and inhibitor of NF-κB, 5-LO, Cox-2, COP9, and p300/CBP.
CAS Number	458-37-7
Purity	≥95%
Molecular Weight	368.38
Molecular Formula	C₂₁H₂₀O₆

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Refer to Certificate of Analysis for lot specific data (including water content).

Curcumin is a yellow-orange dye obtained from tumeric, the powdered root of Curcuma longa. Curcumin is employed in the preparation of curcuma paper, the detection of boron, and possesses a vast number of biological targets. Curcumin has been shown to inhibit NF-κB, possibly through inhibition of JNK (IC50=10 μM). Curcumin blocks amyloid peptide induced expression of: TNF-α, IL-1β, MCP-1, IL-8, and CCR5, regulates NOS2, inhibits IgE and Ag-induced degranulation of mast cells, inhibits 5-LO (5-lipoxygenase) (IC50=8 μM), Cox-2 (cyclooxygenase-2) (IC50=52 μM), the COP9 signalosome kinase (IC50=10 µM), and p300/CBP. This wide range of activities makes Curcumin an extremely useful tool for developing novel analogues and uses.

TECHNICAL INFORMATION

Appearance :	Powder
Physical State :	Solid
Solubility :	Soluble in water (1 mg/ml), and ethanol (1%). Insoluble in acetone.
Derived From :	Turmeric rhizome
Solubility :	Soluble in DMSO (25 mg/ml), acetic acid, 0.1M NaOH, 10mM Na2CO3, acetone, water (< 0.1 mg/ml), and chloroform. Insoluble in ethanol.
Storage :	Store at room temperature
Melting Point :	170-175° C
Boiling Point :	~591.4° C at 760 mmHg (Predicted)
Density :	~1.3 g/cm3 (Predicted)
Refractive Index :	n²⁰_D 1.42
IC50 :	5-lipoxygenase: IC50 = 8 µM; cyclooxygenase: IC50 = 52 µM; nitric oxide synthase in activated macrophages: IC50 = 6 µM

SAFETY INFORMATION

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :	3
PubChem CID :	969516
RTECS :	MI5230000
Merck Index :	14: 2673
MDL Number :	MFCD00008365
EC Number :	207-280-5
Beilstein Registry :	2306965
SMILES :	COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O