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Thioflavin T
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Tristains

S10188

Thioflavin T

CAS No
2390-54-7
Synonym(s)
Basic Yellow 1
Molecular Formula:
C17H19ClN2S
Molecular Weight:
318.86
EC Number:
219-228-9
Colour Index Number:
49005
PubChem CID:
16953
MDL number:
MFCD00011944
Specification SDS Available pack size: 100g, 10g, 25g, 50g, 5g
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Description

Thioflavin T CAS: 2390-54-7 | MF: C17H19ClN2S | MW: 318.86, Buy Histological Stains & Dyes for Histology, Cytology, Microbiology, Hematology & Biology Lab from TriStains.

Thioflavin T (2390-54-7) is widely used in the field of research laboratories as a benzothiazole-based fluorescent dye specifically adapted to detect amyloid. This is a specialized stain, which has an increased fluorescence when attached to amyloid fibrils by a characteristic spectral shift. It is a powerful fluorescent dye that produces fluorescence under UV or blue light, which renders it a significant dye to be utilized in identifying and studying the structure of amyloid in tissue samples and cell culture samples. Just like Thioflavin S, Thioflavin T is a compound with a methyl thio functional group, but it is different with respect to solubility characteristics and usage procedures. Its versatility supports a broad spectrum of methods of laboratory procedures, which are fluorescence microscopy, spectrofluorometric analysis, and quantitative amyloid fibril detection assays.

Applications

  • Cytology and Histology: Allows visualization of aggregates of proteins in fixed tissue sections, as well as in cultured cellular preparations.
  • Microbiology: Assists in the recognition of functional amyloids in bacterial biofilms.
  • Hematology: Applied in the staining of amyloid or protein in the peripheral blood smears and bone marrow samples.
  • Protein Aggregation Studies: Is important in the study of the kinetics of the amyloid fibril formation under in vitro conditions.

Key features

  • Strong affinity towards amyloid fibrils.
  • High levels of fluorescence on binding.
  • Appropriate for quantitative fluorescence methods and imaging.
  • Can be readily modified to standardized staining methods.

General Description

Thioflavin T (CAS No. 2390-54-7) is a common fluorescent dye that has a high affinity to ?-sheet-rich amyloid structures. Its intense fluorescence at the right excitation gives it clarity and resolution, rendering it indispensable in neuroscience, pathology, and cell biology studies. A highly selective fluorescent stain is needed to identify and accurately distinguish the clinical and research samples that have protein aggregates or amyloid fibrils.

Want to buy Thioflavin T? TriStains sells high-quality Thioflavin T, which is produced to laboratory standards to guarantee consistency of performance and reproducible staining results. TriStains is a reliable provider of histological stains and biological dyes used in histology, cytology, microbiology, hematology, and life science research laboratories, and provides quality-tested products to be used worldwide in research. Thioflavin T is available in several pack sizes with comprehensive technical requirements to aid laboratory protocols. The sales department may be used to order institutional bulk quantities or tailor-made quotations by the researchers and institutions. Purchase Thioflavin T (CAS: 2390-54-7 MF: C17H19ClN2S MW: 318.86) – an amyloid detection fluorescent histology stain with high performance, sold by TriStains to researchers and diagnostic laboratory users.

About Brand

TriStains provides a marketplace for histology and biological stains, which is comprehensive enough to encompass the peculiar requirements of laboratories specializing in Histology, Cytology, Microbiology, and Hematology. With a reputation for exceeding quality expectations, TriStains performance is outstanding which allows for resolution of cell and tissue components fundamental to life sciences to be clearly visualized. Each product under TriStains series is validated for accuracy, reliability and consistency. TriStains, which manufactures and markets stains and indicators in various packing, offers laboratories turn key solutions for all their staining and indicator needs, improving accuracy in every experiment.

Additional information
Brand

Tristains

Size

100g, 10g, 25g, 50g, 5g

CAS No

2390-54-7

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TECHNICAL INFORMATION
Alternate Names Basic Yellow 1
Application Thioflavin T is a cell-permeable dye capable of binding amyloid fibrils
CAS Number 2390-54-7
Molecular Weight 318.86
Molecular Formula: C17H19ClN2S

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Thioflavin T is a cell-permeable benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils. Thioflavin T is useful in monitoring stacked β sheet aggregates.

TECHNICAL INFORMATION

Physical State Solid
Solubility Soluble in water (5 mg/ml), alcohol (100 mg/ml), methanol (0.1% w/v), and glacial acetic acid:water (1:1) (50 mg/ml).
Storage Store at room temperature
Melting Point >100° C
Fluoresence λex ~385 nm-free (~437 nm), λem ~445 nm-free (~485 nm); λex 350 nm, λem 438 nm; λex 450 nm, λem 482 nm

SAFETY INFORMATION

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany 3
PubChem CID 16953
MDL Number MFCD00011944
EC Number 219-228-9
Beilstein Registry 3922452
SMILES CC1=CC2=C(C=C1)[N+](=C(S2)C3=CC=C(C=C3)N(C)C)C.[Cl-]

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